Buy Dermorphin: High-Purity μ-Opioid Receptor Agonist for Research
If you are looking to buy dermorphin for neuroscientific or pharmacological research, ensuring high chemical purity and sequence integrity is paramount. Dermorphin is a natural heptapeptide originally isolated from the skin of South American frogs (Phyllomedusa sauvagei). It is renowned in the scientific community as a highly potent and selective μ-opioid receptor (MOR) agonist.
What is Dermorphin?
Dermorphin is a unique bioactive peptide with the sequence H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2. It is distinguished by the presence of a D-alanine residue at the second position—a rare post-translational modification in vertebrate peptides that is critical for its biological activity and resistance to metabolic degradation.
Researchers who buy dermorphin often utilize it as a “gold standard” in studies involving opioid receptor signaling, pain modulation, and gastrointestinal motility due to its exceptional affinity for the μ-type receptor.
Key Research Applications and Benefits
When you integrate dermorphin into your experimental protocols, you are working with a peptide that offers significant advantages over traditional alkaloids:
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Extreme Potency: Dermorphin is estimated to be 30 to 40 times more potent than morphine in analgesic assays, particularly when administered centrally or intrathecally.
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High Selectivity: It exhibits sub-nanomolar affinity for the Mu-opioid receptor, with significantly lower affinity for delta and kappa receptors.
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Neuropathic Pain Studies: It is a primary tool for studying the inhibition of noxious stimuli-induced neuronal firing and the development of non-narcotic analgesic alternatives.
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Gastrointestinal Research: Clinical models show that dermorphin significantly delays gastric emptying and slows colonic motility.
Technical Specifications
Before you buy dermorphin, confirm these technical parameters to ensure compatibility with your needs:
| Attribute | Specification |
| CAS Number | 77614-16-5 |
| Molecular Formula | $C_{40}H_{50}N_{8}O_{10}$ |
| Molecular Weight | 802.87 g/mol |
| Sequence | Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2 |
| Purity | ≥98% (HPLC verified) |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in Water, DMSO, or PBS (pH 7.2) |
Handling and Storage Guidelines
To maintain the stability of the peptide after you buy dermorphin:
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Storage: Keep the lyophilized powder at -20°C in a desiccated environment. For long-term preservation, -80°C is recommended.
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Reconstitution: Use sterile, deionized water or buffered solutions.
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Stability: Once in solution, the peptide is stable for approximately one month if stored at -20°C. Avoid repeated freeze-thaw cycles by creating single-use aliquots.
Why Buy Dermorphin from a Verified Source?
In the landscape of modern pharmacology, the quality of your raw materials determines the reliability of your data. As of 2026, dermorphin remains a vital candidate for researching palliative care and chronic pain management. Always request a Certificate of Analysis (CoA) and Mass Spectrometry (MS) data to confirm the D-Ala configuration and chemical purity.



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